Two sample MR report
HLA-A_Conventional Dendritic Cell against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 38 | -0.0092582 | 0.0469144 | 0.8446691 |
| Weighted median | 38 | 0.0447610 | 0.0050097 | 0.0000000 |
| Inverse variance weighted | 38 | 0.0425039 | 0.0036321 | 0.0000000 |
| Simple mode | 38 | 0.0486842 | 0.0098585 | 0.0000171 |
| Weighted mode | 38 | 0.0472205 | 0.0095049 | 0.0000156 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 18.96790 | 36 | 0.9912120 |
| Inverse variance weighted | 20.19258 | 37 | 0.9888546 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0287993 | 0.0260238 | 0.2757846 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000846 | 1e-07 | TRUE | 0.0061723 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
